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Listar por autor "Cordero, Mario D."
Mostrando ítems 1-20 de 20
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Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds
Marín-Aguilar, Fabiola; Pavillard, Luis E.; Giampieri, Francesca; Bullon, Pedro; Cordero, Mario D. (Molecular Diversity Preservation International (MDPI), 2017)Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in ...
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Aging-Related Changes in Inflammatory and LKB1/AMPK Gene Expression in Fibromyalgia Patients
Alcocer-Gómez, Elísabet; Sánchez-Alcazar, José Antonio; Battino, Maurizio; Bullon, Pedro; Cordero, Mario D. (Wiley-Blackwell Publishing Ltd., 2014-03-19)Aging is characterized by a progressive loss of physiological integrity, leading to the impairment of numerous functions ...
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Apoptotic microtubules delimit an active caspase free area in the cellular cortex during the execution phase of apoptosis
Oropesa-Avila, M.; Fernandez-Vega, A.; Mata Fernández, María de la; Maraver, J. G.; Cordero, Mario D.; Cotán, D.; Miguel Rodríguez, Manuel de; Sánchez-Alcázar, José Antonio (NATURE PUBLISHING GROUP, 2013)Apoptotic microtubule network (AMN) is organized during apoptosis, forming a cortical structure beneath plasma membrane, which ...
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Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment
Bullon, Pedro; Castejón Vega, Beatriz; Román-Malo, Lourdes; Jimenez-Guerrero, María Paz; Cotán, David; Cordero, Mario D. (2018)Background: Cathepsin C (CatC) is a lysosomal enzyme involved in activation of serine proteases from immune and ...
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Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation
Bullon, Pedro; Cordero, Mario D.; Quiles, Jose Luis; Ramirez Tortosa, Maria Carmen; González Alfonso, Adrián; Alfonsi, Simona; García Marín, Mª del Rocío; Miguel Rodríguez, Manuel de; Battino, Maurizio (2012) -
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Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns
Pavillard Rodríguez, Luis Eugenio; Marín Aguilar, Fabiola; Bullon, Pedro; Cordero, Mario D. (Elsevier, 2018-05)Cardiovascular diseases (CVD) are the leading cause of death worldwide, with high prevalence in industrialized countries. ...
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Coenzyme Q(10) Therapy
Garrido-Maraver, Juan; Cordero, Mario D.; Oropesa-Ávila, Manuel; Fernández Vega, Alejandro; Mata, Mario de la; Delgado Pavón, Ana; Miguel Rodríguez, Manuel de; Sánchez-Alcázar, José Antonio (KARGER, 2014)For a number of years, coenzyme Q 10 (CoQ 10 ) was known for its key role in mitochondrial bioenergetics; later ...
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Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related Mechanism
Bullon, Pedro; Battino, Maurizio; Varela-Lopez, Alfonso; Ramirez Tortosa, Maria Carmen; Perez Lopez, Patricia; Granados Principal, Sergio; Ochoa, Julio; Cordero, Mario D.; González Alonso, Adrián; Ramírez-Tortosa, César L.; Corrado, Rubini; Zizzi, Antonio; Quiles, José L. (Gabriele Vincenzo Gnoni, University of Salento, Italy, 2013-09-16)Background/Objectives: Aging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. ...
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Inhibition of the NLRP3 inflammasome prevents ovarian aging
Navarro Pando, José Manuel; Alcocer-Gómez, Elísabet; Castejón Vega, Beatriz; Navarro Villarán, Elena; Condés Hervás, Mónica; Mundi Roldán, María; Muntané Relat, Jordi; Pérez Pulido, Antonio J.; Bullon, Pedro; Wang, Chun; Hoffman, Hal M.; Sanz Montero, Alberto; Mbalaviele, Gabriel; Ryffel, Bernhard; Cordero, Mario D. (American Association for the Advancement of Science, 2021)Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of ...
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Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
Cordero, Mario D.; Díaz-Parrado, Eduardo; Carrión, Ángel Manuel; Alfonsi, Simona; Sánchez Alcázar, José Antonio; Miguel Rodríguez, Manuel de; Battino, Maurizio; Miguel Rodríguez, Manuel de (Mary Ann Liebert, Inc., 2013)Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial ...
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L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation
Castejón Vega, Beatriz; Rubio Valle, Alejandro; Pérez Pulido, Antonio J.; Quiles Morales, José Luis; Lane, Jon D.; Fernández Domínguez, Beatriz; Alcocer-Gómez, Elísabet; Cordero, Mario D. (MDPI, 2021)Aims: Tay–Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that ...
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Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation
Forbes Hernandez, Tamara Yuliett; Giampieri, Francesca; Gasparrini, Massimiliano; Afrin, Sadia; Mazzoni, Luca; Cordero, Mario D.; Mezzetti, Bruno; Quiles, José L.; Battino, Maurizio (Molecular Diversity Preservation International, 2017-06-16)Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, ...
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Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
Cordero, Mario D.; Miguel Rodríguez, Manuel de; Moreno-Fernández, Ana María; Carmona López, María Inés; Garrido Maraver, Juan; Cotán, David; Gómez Izquierdo, Lourdes; Bonal Pitz, Pedro Pablo; Campa Valera, Francisco; Bullon, Pedro; Navas, Plácido; Sánchez Alcázar, José Antonio (BioMed Central, 2010)Introduction: Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence ...
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Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis
Díaz, Carmen M.; Bullón de la Fuente, Beatriz; Ruiz Salmerón, Rafael J.; Fernández-Riejos, Patricia; Fernández Palacín, Ana; Battino, Maurizio; Cordero, Mario D.; Quiles, José L.; Varela-López, Alfonso; Bullon, Pedro (Blackwell Munksgaard, 2020)Background and Objective. Our aims were to improve the understanding of the pathogenic relationship between cardiovascular ...
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NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
Marín‐Aguilar,Fabiola; Lechuga‐Vieco, Ana V.; Alcocer‐Gómez, Elísabet; Castejón Vega, Beatriz; Lucas, Javier; Bullon, Pedro; Cordero, Mario D. (Willey, 2019-09-23)While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely ...
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NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.
Marín-Aguilar, Fabiola; Lechuga‐Vieco, A.V.; Alcocer-Gómez, Elízabet; Castejón Vega, Beatriz; Lucas, Javier; Garrido, Carlos; Peralta García, Alejandro; Pérez‐Pulido, Antonio J.; Varela‐López, Alfonso; Bullon, Pedro; Cordero, Mario D. (John Wiley & Sons Ltd and The Anatomical Society, 2019-09-23)While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely ...
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NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
Pavillard, Luis E.; Cañadas Lozano, Diego; Alcocer-Gómez, Elísabet; Marin Aguilar, Fabiola; Pereira Arenas, Sheila; Robertson, Avril; Muntané Relat, Jordi; Bullon, Pedro; Cordero, Mario D. (Impact Journals, 2017)The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction ...
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Oxidative stress and dietary fat type in relation to periodontal disease
Varela-Lopez, Alfonso; Quiles, José L.; Cordero, Mario D.; Giampieri, Francesca; Bullon, Pedro (MDPI AG, 2015-04-28)Oxidative stress is one of the main factors studied to explain the pathophysiological mechanisms of inflammatory conditions, ...
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Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre
Castejón Vega, Beatriz; Battino, Maurizio; Quiles, José L.; Bullón de la Fuente, Beatriz; Cordero, Mario D.; Bullon, Pedro (MDPI, 2021)The Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) ...
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Utility of Periodontal exploration in patients with Fibromyalgia
Bullon, Pedro; Santos García, Rocío; Sánchez Domínguez, Benito; Cordero, Mario D.; Ríos-Santos, J.V.; Jaramillo Santos, María Reyes; Herrero Climent, Mariano (2012)Objetive: Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology, which affects predominantly ...